ARTIGOS SOBRE NEUROIMAGENS (Neuroimaging)

Hegde AN, Mohan S, Lim CCT. CNS cavernous haemangioma: “popcorn” in the brain and spinal cord. Clin Radiol 2012;67:380-388. Morris Z, Whiteley WN, Morris Z, Longstreth WT Jr, Weber F, Lee YC, Tsusushima Y, Ladd SC, Warlow C, Wardlaw JM, Al-Shahi Salman R. Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis. Br Med J 2009; 339: b3016. Lehnhardt FG. Valeu of gradient-echo magnetic resonance imaging in the diagnosis of familial cerebral cavernous malformation. Arch Neurol 2005;62:653-658. De Souza JM, Domingues RC, Cruz JRLCH, Domingues FS, Iasbeck T e Gasparetto EL. Susceptiblility-Weight imaging for the evaluation of patients with familial cerebral cavernous malformations: a comparison with T2-weighted fast spin-echo and gradient-echo sequences. AJNR Am J Neuroradiol 2008;29:154-58. Champfleur NM, Ankenbrandt WJ, Le Bars E, Leroy MA, Duffau H, Bonafé A, Awad I, Pierre Labauge. Magnetic resonance imaging evaluation of cerebral cavernous malformations with susceptibility-weighting imaging. Neurosurgery 2011;68:641-648.

ARTIGOS SOBRE HISTÓRIA NATURAL (Natural History)

Barker FG, Amin-Hanjani S, Butler WE, Sepideh AH, Ojeman RG, Chapman PH, Ogilvy CS. Temporal clustering of hemorrhages from untreated cavernous malformations of the central nervous system. Neurosurgery 2001;49:15-25. Khakar S, Shuck J, Conway J, Rigamonti D. The natural history of conservatively managed spinal cord cavernomas. Neurosurgery 2007;60:865-872. Batra S, Lin D, Recinos P, Rigamonti D. Cavernous Malformations: natural history, diagnosis and treatment. Nat Rev Neurol 2009;5:659-670. Gross BA, Lin N, Du R et al. The natural history of intracranial cavernous malformations. Neurosurg Focus 2011;30(6): E24. Al-Shahi R, Hall JM, Moultrie F, Hall JM, Bhattacharya JJ, Counsell CE, Murray GD, Papanastassiou V, Ritchie V, Roberts RC, Sellar RJ, Warlow CP. Untreated clinical course of cerebral cavernous malformations: a prospective, population-based cohort study. Lancet Neurol 2012;11:217-24. Gault J, Sain S, Awad IA. Sectrum of genotype and clinical manisfestations in cerebral cavernous malformations. Neurosurgery2006;59:1278-1284. Vishteh, AG, Zabrambski JM, SpetzlerRF. Patients with spinal cord cavernous malformations are at incrased risk for multiple neuraxis cavernous malformations. Neurosurgery 1999;45:30-32. Larson JJ, Ball WS, Bove KE. Formation of intracerebral cavernous malformation after radiation treatment for central nervous system neoplasia in children. J Neurosurg 1998;88:51-56.

ARTIGOS SOBRE SINALIZAÇÃO CELULAR (Signaling )

Whitehead KJ, Chan AC, Navankasattusas S, Kohl W, London NR, Ling J, Mayo AH, Drakos SG, Marchuk DA, Davis GE, Li DY. The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med 2009;15(2):177-184. Stockton R, Shenkar R, Awad IA, Ginsberg MH. Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med 2010;207(4):881-896. Yadla S, Jabbour PM, Shenkar R, Shi C, Campbel PG, Awad IA. Cerebral cavernous Malformation as a disease of vascular permeability: from bench to bedside with caution. Neurosurg Focus 2010;29(3):E4. Richardson BT, Dibble CF, Borikova AL, Johnson GL. Cerebral cavernous malformation disease associated with activated RhoA signaling. Biol Chem 2012;394:35-42.

ARTIGOS SOBRE ASSOCIAÇÃO COM ANGIOMA VENOSO OU ANOMALIA VENOSA DE DESENVOLVIMENTO (DVA and cavernous malformations)

Petersen TA, Morrison LA.Schrader RM and Hart BL. Familial versus sporadic cavernous malformations: differences in developmental venous anomaly association and lesion phenotype. AJNR Am J Neurorad 2010;31:377-382. Abdulrauf S, Kaynar M and Awad IA. A comparison of the clinical profile of cavernous malformations with and without associated venous malformations. Neurosurgery 1999;44:41-46. Awad I, Robinson JR, Mohanty S, Estes ML. Mixed vascular malformations of the brain: clinical and pathogenetic considerations. Neurosurgery 1993;33(2):179-88. Perrini P and Lanzino G. The association of venous developmental anomalies and cavernous malformations: pathophysiological, diagnostic and surgical considerations. Neurosurgical Focus 2006;21:1-4. WurmG, Schnizer M, Fellner F. Cerebral cavernous malformations associated with venous anomalies: surgical considerations. Neurosurgery 2005;57:42-58.

ARTIGOS SOBRE GENÉTICA (Genetics)

Gunel M, Awad IA. A founder mutation as a cause of cerebral cavernous malformation in Hispanic Americans. New England J Med 1996;334:946-951. Labauge P, Denier C, BergamettiF, Tournier-Lasserve E. Genetics of cavernous angiomas Lancet Neurol 2007;6:237-44. Ortiz L, Costa AF, Bellido M. Study of cerebral cavernous malformation in Spain and Portugal. High prevalence of 14 bp deletion in exon 5 of MGC4607 (CCM2) gene. J Neurol 2007;254:322-326. Marcondes de Souza J, Domingues FS Chimelli L, Gault J. Spinal root arteriovenous malformation and same-segment spinal cord cavernous malformation in a familial cerebral cavernous malformation. J Neurosurg Spine 2008;9:249-2008). LIquori, CL, Berg MJ. Low frequency of PDCD10 mutations in a panel of CCM3 probands: ppotential for a fourth CCM locus. Hum Mut 2006;27:118. Gault J, Shenkar R,Recksiek P, Awad IA. Biallelic somatic and germline CCM1 truncating mutations in a cerebral cavernous malformation lesion. Stroke2005;36:872-874.

ARTIGOS SOBRE TRATAMENTO (Clinical management)

Recinos F, Lo SLL, and Rigamonti D. The pros and cons of conservative and surgical treatment of cavernous malformations. Em Daniele Rigamonti, ed. Cavernous Malformations of the Nervous System., 1th ed. (Cambridge University Press, 2011) pp1030113. Gross BA, Batjer HH, Awad IA. Cavernous malformations of the basal ganglia and thalamus. Neurosurgery 2009;65:7-18. Pham M, Gross B, Nedock B. Radiosurgery for angiographically occult vascular malformations. Neurosurg Focus 2009;26:E16. Gross BA, Batjer HH,Awad IA. Brainstem cavernous malformations. Neurosurgery 2009;64:E805-818. Domingues F, Gasparetto E, Andrade R, Gasparetto E, Desouza JM. Familial cerebral cavernous malformations: Rio de Janeiro study and review of the recommendations for management. Arq Neuropsiquiatr 2008;66(4):795-799 Hasegawa T, McInerney J, Kondziolka D. Long term results after stereotactic radiosurgery for patients with cavernous malformations. Neurosurgery 2002;50:1190-1197. Visteh AG, Sankhla S, Anson JA, Zabramski JM and Spetzler RF. Surgical resection of intramedullary spinal cord cavernous malformations: delayed complications, long-term outcomes and association wit cryptic venous malformations. Neurosurgery 1997;41:1094-1100. Visteh AG, Spetzler RF. Radical excision of intramedullary cavernous angiomas. Neurosurgery 1999;44:428. Moultrie F, Home, MA, Josephson CB, Hall JM, Counsell CE, Bhattacharya V, SEllar RJ, Warlow CP, Al-Shahi R and Scotish Audit of Intracranial Vascular malformations Steering Committee. Outcome after surgical or conservative management of cerebral cavernous malformations. Neurology 2014;83:582-589.

ARTIGOS SOBRE MODELOS DE ESTUDO DE MEDICAÇÕES

McDonald DA, Shi C, Shenkar R, Stockton RA, Liu F, Ginsberg MH, Marchuk DA, Awad IA. Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. Stroke 2012;43:571-574. Whitehead KJ, Chan AC, Navankasattusas S, Kohl W, London NR, Ling J, Mayo AH, Drakos SG, Marchuk DA, Davis GE, Li DY. The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med 2009;15(2):177-184.

ARTIGOS SOBRE EPILEPSIA E CAVERNOMA ( Cavernous malformation and epilepsy)

Josephson CB, Leach JP, Duncan R. Seizure risk from cavernous malformations of the brain : prospective population-based study. Neurology2011;76:1548-54. Awad I and Jabbour P. Cerebral cavernous malformations and epilepsy. Neurosurgical Focus 2006;21(E7):1-9. Gompel JJ, Marsh WR, Meyer FB, Worrell GA. Patient-assessed satisfaction and outcome after microsurgical resection of cavernomas causing epilepsy. Neurosurg Focus 2010;29(3):1-5.

ARTIGOS SOBRE HEMORRAGIA EM CAVERNOMA CEREBRAL

Al-Shahi Salman, R., Berg, M., Morrison, L., Awad, I. & Angioma Alliance Scientific Advisory Board. Hemorrhage from cavernous malformations of the brain: definition and reporting standards. Angioma Alliance Scientific Advisory Board. Stroke 2008; 39: 3222–3230. Safavi-Abbasi S et al. Hemorrhage of cavernous malformation during pregnancy and in the peripartum period: causal or coincidence ?Case report and review of the literature. Neurosurg Focus 2006;21:e12.